Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) Size:10mg 968 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

968 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Degrader building block for targeted protein degradation

Datasheet         MSDS

and lung cancers

It is based on a proximity-induced covalent Michael addition between an engineered cysteine (Cys) residue in Escherichia coli dihydrofolate reductase (eDHFR) and optimized trimethoprim (TMP)-acrylamide conjugates with minimal linker lengths

Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) Size:10mg 968 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase